Radiology Search - The Right Place for Searching Radiology Information ... A Radiology search engine developed for Radiologists by Radiologists ...
...the most exciting new development in modernized patient care...(read more)
Search Radiology contents from thousands of peer reviewed Radiology websites and hundreds of Radiology journals!



Include: Semantic search :: Video search :: Quick image search
My Search :: About :: What's new :: Forum :: Online Tutorial :: Feedback :: Contact Us :: Home


Bookmark and Share

Published: . Dec 2014


Kagna O, Pirmisashvili N, Tshori S, Freedman N, Israel O, Krausz Y

Neuroendocrine tumor imaging with 68Ga-DOTA-NOC: physiologic and benign variants.
(AJR Am J Roentgenol)

Imaging with (68)Ga-labeled 1,4,7,10-tetraazacyclododecane-1,4,7,10-tetraacetic acid (DOTA)-octreotide analogs has become an important modality in patients with neuroendocrine tumors (NETs). In addition to high uptake in NET lesions, prominent physiologic radiotracer activity has been reported in the pituitary gland, pancreas, adrenal glands, liver, and spleen, and faint activity has been reported in the thyroid and gastrointestinal tract. This article describes previously unknown sites of 68Ga-DOTA-1-NaI3-octreotide (NOC) uptake unrelated to NETs. One hundred eighty-two patients (96 female and 86 male patients; age range, 4-89 years) with documented (n=156) or suspected (n=26) NETs underwent 207 68Ga-DOTA-NOC PET/CT studies. Studies were retrospectively reviewed for the presence, intensity, and localization of foci of increased uptake that were further correlated with findings on additional imaging studies and clinical follow-up for a period of 4-32 months. Uptake of 68Ga-DOTA-NOC not identified as NET or known physiologic activity was detected in 297 sites with confirmation in 149 of 207 studies (72%). The most common location of non-NET-related 68Ga-DOTA-NOC-avid sites was in small lymph nodes, followed by prostate, uterus, breasts, lungs, brown fat, musculoskeletal system, and other sites, including oropharynx, pineal body, thymus, aortic plaque, genitalia, surgical bed, and subcutaneous granuloma. Intensity of uptake in non-NET-related 68Ga-DOTA-NOC-avid sites ranged in maximum standardized uptake value from 0.8 to 10.5. Previously unreported benign sites of 68Ga-DOTA-NOC uptake were found in the majority of studies, suggesting the presence of somatostatin receptors in physiologic variants or processes with no evidence of tumor. Knowledge of increased tracer uptake in non-NET-related sites is important for accurate interpretation and for avoiding potential pitfalls of 68Ga-DOTA-NOC PET/CT.

-> Read fulltext

Read more articles from the authors:
1. Kagna O
2. Pirmisashvili N
3. Tshori S
4. Freedman N
5. Israel O
6. Krausz Y


Related articles

Read abstract in PubMed

Do search in PubMed

Copy citation:

Export to Bibtex
Export to EndNote
Export to Reference Manager



Bookmark and Share

Add to Yahoo    Add to Del.icio.us    Add to Google    Add to AOL    Add to Furl    Add to Connotea    Add to Citeulike    Add to Stumbleupon    Add to Dissect medicine    Add to 2collab   

Add Radiology Search to your search engines :: Put Radiology Search on your website :: Make Radiology Search your homepage :: Add Radiology Search to your favorites
© 2017 Radiology Search